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The Frame pattern is a caused by a dominant gene. In the
past Frame was thought to be recessive because "Overo"
foals have been produced out of parents with no white on the
body, these are usually called "crop-outs". Frame
has even been called a "dominant-recessive" which
makes absolutely no sense. It is much more reasonable and
has been proven by further research, that these solid horses
are minimally marked individuals that do not have body spots,
but do have other characteristics of the Frame pattern and
as such they are producing the same as any heterozygous, Frame
horse that have white on their bodies. Frame in a minimal
expression is very common and occurs in all breeds in which
Frame is found. Some Frame horses are so minimal they don't
have any white, just blue eyes. You could have horses with
the Frame pattern in your herd and not even know it. This
is why the Frame/Lethal White test is so important.
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The Frame gene in homozygous form is lethal and produces
foals that are have OLWS (Overo Lethal White Syndrome). These
foals are carried full term, born totally white, although
some may have a tiny spot or two of color. These foals have
an incomplete lower colon and because of this the foals cannot
defecate and die of colic shortly after birth. It is recommended
that these foals be humanly euthanized, but it is very
important to know for sure that a white foal is in fact a
Lethal White because white foals can be born that are totally
healthy and normal. These would be horses with the maximum
expression of their particular pattern or several patterns
on the same horse.
A perfect example of a white foal that is perfectly healthy
is the one to the left. His sire is a Chestnut Frame + Splash
+ Sabino and his dam is a Bay Tobiano + Sabino. It is possible
that Houstan carries all four Pinto patterns. Since he is
totally white, his base coat is undetermined at this time.
Since his sire is Chestnut and his dam is Bay his base color
could be Black, Bay or Chestnut.
There is a test that can be done to determine if a horse
is a OLWS carrier. For more info, click
here.
Frame is designated by "Fr". Since it is dominant,
the first letter is capitalized. Since there are two locations
for a gene the other space must be filled up with something.
In the case of heterozygous individuals the lower case letter
is used indicating the gene is not present. All horses
that have the Frame pattern have it genetically symbolized
by "Frfr". With "Fr" being the gene that
makes the horse Frame, or the dominant form of Frame. "fr"
is the other half of the genetic code at that particular locus
and only indicates that the Frame gene is present in one dose.
By using a Punnet Square, it's very easy to figure out the
what the chances are of producing a OLWS foal when two Frame
horses are bred.
The
white square indicates that a OWLS foal was conceived. The
grey squares indicate normal Frame foals and the yellow square
indicates the foal does not have the Frame gene.
By using this simple chart one can see how we come up with
the 25% being the chances of a OWLS foal being produced from
two Frame parents. The percentages are only applicable at
each breeding, not throughout the horses entire reproductive
life.
Horses that do not appear to have body spots and be Frame
physically can still be carriers of the gene, this is why
it is important to have your horses tested even if you don't
think it has Frame in it's background and you plan on breeding
it to other Frame horses.
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